AI-generated practice question — model-generated for extra practice, not a previous-year CBSE board question.
The fact that smallpox spread deep into America before Europeans physically arrived there is historically significant because it shows that disease alone — not just military force — destroyed entire indigenous communities. America's original inhabitants had no immunity due to their long isolation, making them fatally vulnerable. This reveals that European conquest was not simply a result of superior firepower. The real weapon was biological: germs carried by Europeans decimated whole populations, clearing the way for colonisation and making conquest far easier than it would otherwise have been.
Source: Chapter 3, Section 1.3 — Conquest, Disease and Trade
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