AI-generated practice question — model-generated for extra practice, not a previous-year CBSE board question.
Option B is correct. America's original inhabitants had no immunity against smallpox because of their long isolation from the rest of the world, making it a deadly killer that decimated whole communities.
Source: Conquest, Disease and Trade, Chapter 3
The passage explicitly states: "Because of their long isolation, America's original inhabitants had no immunity against these diseases that came from Europe." The Spanish had been exposed to smallpox in Europe over generations and had developed immunity. Option A is wrong as no medical treatment is mentioned; C is wrong as smallpox was a European disease; D is wrong as the passage says it spread naturally, not deliberately through weapons.