AI-generated practice question — model-generated for extra practice, not a previous-year CBSE board question.
America was cut off from regular contact with the rest of the world for millions of years before the sixteenth century. Due to this long geographical isolation, its indigenous people were never exposed to diseases like smallpox, which were common in Europe and Asia. As a result, they developed no natural immunity against these germs. When European settlers arrived carrying these diseases, the diseases spread rapidly deep into the continent, killing and decimating whole communities even before Europeans physically reached those areas. This paved the way for conquest and colonisation.
Source: Chapter 3, Section 1.3 — Conquest, Disease and Trade
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